Serotonin Norepinephrine Dopamine Reuptake Inhibitor

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A serotonin–norepinephrine–dopamine reuptake inhibitor, or triple reuptake inhibitor, is a drug/ligand that simultaneously acts as a reuptake inhibitor for the monoamine neurotransmitters, serotonin, norepinephrine and dopamine, by blocking the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter, respectively. This, in turn, leads to increased extracellular concentrations of these neurotransmitters and, therefore, an increase in serotonergic, noradrenergic or adrenergic, and dopaminergic neurotransmission. In this sense, to a degree, there is omnipresence in what these compounds do. This group of drugs/ligands are believed to work in much the same way as the nonselective monoamine releasers, albeit through a differing mechanism of activity.
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